UCI Chem 128 Introduction to Chemical Biology (Winter 2013)
Lec 09. Introduction to Chemical Biology -- RNA -- Part 2
View the complete course: ../courses/chem_128_introduction_to_chemical_biology.html
Instructor: Gregory Weiss, Ph.D.
License: Creative Commons BY-NC-SA
Terms of Use: ../info.
More courses at http://ocw.uci.edu
Description: This video is part of a 18-lecture undergraduate-level course titled "Introduction to Chemical Biology" taught at UC Irvine by Professor Gregory Weiss. Introduction to the basic principles of chemical biology: structures and reactivity; chemical mechanisms of enzyme catalysis; chemistry of signaling, biosynthesis, and metabolic pathways.
Introduction to Chemical Biology (Chem 128) is part of OpenChem: ../openchem
Recorded on February 7, 2013.
Index of Topics:
Announcements
0:00:08 - Week 5 Overview
0:01:44 - Announcements
0:01:50 - Office Hours
0:02:09 - Important Book Report Announcements
0:07:49 - Scientific Writing
0:12:16 - Plagiarism
Lecture
0:21:06 - Our Story Thus Far on Thursday
0:25:41 - RNA: Soldier, Sailor, Tinker, Spy
0:26:04 - Comparing Bacterial and Eukaryotic mRNA Processing
0:27:05 - mRNA Processing in Human Cells
0:28:40 - mRNA Capping in Eukaryotic Cells
0:29:08 - GTP Cap Methylation
0:30:30 - Using PolyA tails to Isolate mRNA
0:34:29 - Eukaryotic Splicing of mRNAs
0:35:25 - Self-Splicing by Some RNA Introns
0:37:38 - RNA Degradation Plays a Major Role
0:40:40 - Therapeutic Anti-Sense
0:42:32 - Modifying the Oligo Backbone
0:44:20 - RNA Interference Used Extensively in the Lab
0:47:57 - Where Peptide Synthesis Starts
0:49:13 - Formation of Peptides by Aminolysis
0:52:49 - The Ribosome Catalyzes Peptide Bond Formation
0:53:46 - Tetracycline Blocks the Ribosome
0:54:51 - Antibiotics Targeting Ribosome and Protein Translation Machinery
0:56:36 - Translation Starts with the Start Codon
0:57:19 - tRNAs Bring Amino Acids to the Ribosome
0:58:26 - The Genetic Code: The Language of the Codons
1:00:33 - Decoding the DNA to Protein Sequence
1:01:43 - How to Load the Amino Acyl tRNA
1:03:50 - Need to Activate the Amino Acid for Loading on the tRNA
1:06:38 - Post-Translational Modification of the N-Terminus
1:07:25 - Inhibiting Methionine Aminopeptidase
1:09:59 - Binding to mRNA Provides Further Regulation of Translation
1:10:59 - Incorporating Unnatural Amino Acids
1:12:38 - Expanding the Protein Palette
1:13:48 - mRNA Aptamer Libraries
1:18:18 - Puromycin Allows Covalent Linkage to the Growing Peptide During Translation
Required attribution: Weiss, Gregory Introduction to Chemical Biology 128 (UCI OpenCourseWare: University of California, Irvine), ../courses/chem_128_introduction_to_chemical_biology.html. [Access date]. License: Creative Commons Attribution-ShareAlike 3.0 United States License.
