UCI Chem 128 Introduction to Chemical Biology (Winter 2013)
Lec 08. Introduction to Chemical Biology -- RNA
View the complete course: ../courses/chem_128_introduction_to_chemical_biology.html
Instructor: Gregory Weiss, Ph.D.
License: Creative Commons BY-NC-SA
Terms of Use: ../info.
More courses at http://ocw.uci.edu
Description: This video is part of a 18-lecture undergraduate-level course titled "Introduction to Chemical Biology" taught at UC Irvine by Professor Gregory Weiss. Introduction to the basic principles of chemical biology: structures and reactivity; chemical mechanisms of enzyme catalysis; chemistry of signaling, biosynthesis, and metabolic pathways.
Introduction to Chemical Biology (Chem 128) is part of OpenChem: ../openchem
Recorded on February 5, 2013.
Index of Topics:
Announcements
0:00:21 - Announcements
0:01:24 - Midterm 1 Results
0:03:24 - Office Hours
0:04:28 - Getting Strong Letters of Recommendation
0:15:10 - Getting Strong Letters of Recommendation from Prof. Weiss
Lecture
0:18:00 - Our Story Thus Far
0:21:00 - RNA: Soldier, Sailor, Tinker, Spy
0:22:40 - Differences Between RNA and DNA
0:23:25 - RNA Hydrolysis
0:24:29 - The Ubiquitous RNases
0:27:27 - RNase Mechanism of Action
0:30:38 - How to Shut Down a Very Effective Enzyme
0:33:25 - The 5-methyl Group of Thymine Provides a Chemical Code for DNA
0:36:35 - RNA Bases can be Modified
0:38:14 - RNA Adopts Globular Structures
0:40:14 - Systemizing Structure in RNA
0:43:56 - Canonical RNA Secondary Structures
0:45:46 - Systemizing Structure in RNA (revisited)
0:46:20 - RNA Polymerase Catalyzes mRNA synthesis
0:48:34 - RNA Polymerase
0:50:40 - DNA Primase Provides the RNA Primers for DNA Replication
0:52:01 - DNA Primase Synthesizes a Primer for RNA Polymerase
0:52:27 - Transcription in Action
0:54:01 - Examples of Protein DNA Interactions
0:55:56 - Giddayap! TATA Binding Protein Rides the DNA Double Helix
0:57:19 - RNA Transcription Shut Off By Repressors
0:59:16 - Recognition of DNA by transcription factors
1:05:49 - Zinc Finger Transcription Factors
1:08:36 - Engrailed Transcription Factor
1:10:27 - Leucine Zipper Transcription Factor
1:11:12 - Complexity in Activating DNA Transcription
1:11:59 - Small Molecule Control Over Gene Transcription
1:15:32 - The Yeast Two-Hybrid System Allows in Cell Testing for Binding
1:16:49 - The Yeast Two Hybrid System
1:17:53 - Comparing Bacterial and Eukaryotic mRNA Processing
Required attribution: Weiss, Gregory Introduction to Chemical Biology 128 (UCI OpenCourseWare: University of California, Irvine), ../courses/chem_128_introduction_to_chemical_biology.html. [Access date]. License: Creative Commons Attribution-ShareAlike 3.0 United States License.
